The Effects Of Electrical Current On The Bacterial Bacteria

1.1 History In 1965 Barnett Rosenberg made the accidental discovery of the biological use cisplatin whilst conducting an experiment on the effects of electrical current on the bacterial E.coli (Escherichia coli). When the electrical current was turned on, it was observed that the cell division was inhibited causing a decline in the density of the bacterium. However, when the electrical field was turned off, the bacterium returned to its normal density. It was later found that the inhibition of cell division was not due to the electrical current but rather the production of cis- diamminedichloroplatinum (IV) from the platinum electrodes. The trans isomer of the compound was found to be inactive at low concentrations. Other group 10 metal complexes were tested and similar results, however the most effective remained to be the platinum complex. The discovery of this lead to the interest of testing these complexes for their anticancer behaviour. So the platinum (II), cis-[PtCl2(NH3)2], complex and the platinum (IV), cis-[PtCl4(NH3)2] were tested against the Sacroma 180 tumours of Swiss white mice. The complexes showed effective anticancer activity. The large solid tumours were shrunk and the mice lived and they were healthy. The study was so successful the mice even lived another 6 months without any signs of the cancer. This study was the basis in which cisplatin entered clinical trials and have now become one of the most successful anticancer drugs in medicine. 1.2Show MoreRelatedPotential Of Microbial Fuel Cells727 Words   |  3 PagesPotential of Microbial Fuel Cells A microbial fuel cell (MFC) is a device that converts chemical energy to electrical energy by the catalytic and metabolic reactions of microorganisms. The microorganisms function as a catalyst in the electron transfer between the electrodes. A MFC is just like any other fuel cell in its function which can undergo a half cell reaction. 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