Aristotelian Criticism The Monk s Tale - 2417 Words

Aristotelian Criticism: The Monk’s Tale Abstract: Aristotle’s theory of Greek Tragedy was originally intended for Greek plays, but it can be extended to other non-Greek pieces such as novels, short stories, and poetry. The formula contains four key components recommended for tragic tales. The elements of this theory (koros, hubris, ate, and catharsis) can be noted in every tale told by the Monk within The Canterbury Tales, by Geoffrey Chaucer. This relationship will be the main focus of the succeeding composition. Tragic stories can be evaluated in many forms using different methods. One of these approaches, Aristotle’s theory of Greek Tragedy, has become a common formula for examining the value of tragic works. All of the components included in this theory are a reflection of what Aristotle felt made a good tragedy. The elements of this theory (koros, hubris, ate, and catharsis) can be noted in every tale told by the Monk within The Canterbury Tales. One work frequently linked to Aristotle’s theory is the tragic Greek play Oedipus the King, by Sophocles. Perhaps this universal comparison is used due to Aristotle’s high opinion of the work as a perfect tragedy. Although Chaucer’s poem isn’t a Greek play, it would still be prudent to apply the components of Aristotle’s theory to the Monk’s short, tragic tales comprised in â€Å"The Monk’s Tale,† of The Canterbury Tales. In doing so, it will be apparent that Aristotle’s influence reached many future writers, whether they were

Bringing Home Adam Book Critique Free Essays

string(77) " and let them decide what could or could not have been utilized in the case\." Tool would not be formally declared responsible until some twenty seven years later. There are four main points that will be critiqued in this paper. The complications faced by Detective Matthews in working with the Hollywood police Department in trying to solve the case. We will write a custom essay sample on Bringing Home Adam Book Critique or any similar topic only for you Order Now The lack of technology and experience of the Hollywood Police Department concerning the collection of evidence and witness statements. The interagency involvement in finding missing children. The efforts and resources that came about as a result of the Adam Walsh abduction and murder. Analysis Detective Matthews was a polygraph expert with the Miami Beach Police Department. He was asked to assist the Hollywood Police Department with the Adam Walsh case. Throughout the book, the author explains the trials and tribulations that Detective Matthews faced in trying to help the Hollywood Police Department solve the case. Detective Matthews was seen as an outsider from the beginning. He was met with hostility each time he tried to do his job. This was most notably highlighted in the case of Jimmy Campbell. Jimmy Campbell was a family friend and was Adam Walsh’s Godfather. Detective Matthews conducted a polygraph interview of Jimmy Campbell and he was subsequently determined to not have been involved in the abduction and murder of Adam. Though, when Detective Matthews explained who Mr.. Campbell was in relation to the Walsh Family, the lead detective in the case, Detective Jack Hoffman, automatically determined that Mr.. Campbell was the guilty party. It was not long before Detective Matthews was taken off the case. Detective Hoffman explained to Detective Matthews that the case was winding down and that his services would no longer be needed. Stanford Matthews, 2011, p. 6). From the beginning, Detective Hoffman was fixated on Mr.. Campbell, ignoring Detective Matthews’ expertise. Even after having been told that the polygraph indicated no deception in Mr.. Campbell interview, Detective Hoffman based his acquisitions off of subjectivity. Based off of the fact that Mr.. Campbell lived in the Walsh household, had had an affair with Reeve Walsh, a nd had been asked to leave the residence, Detective Hoffman assumed that Mr.. Campbell had committed the crime. Several years later, Detective Matthews would be asked by Hollywood PDP Chief Witt to assist with the case. Detective Matthews anally had the chance to interview Otis Tool but was abruptly removed from case by Chief Witt. It is not exactly clear though, why Detective Matthews received such opposition. The author suggests that it was possible that the Hollywood PDP wanted credit for getting Tool’s confession. It could be possible that by this time, the Hollywood Police Department was trying to do damage control and had known that they let the ball drop in moving forward with handling Tool’s confession. It would be some twenty seven years later when Detective Matthews would be able to complete his investigation, have access to the evidence collected during the investigation, and have access to witnesses, before the Holly. Wood PDP would name Otis Tool as having been responsible for the abduction and murder of Adam Walsh. The authors argues that the lack Of technology and experience Of the Hollywood police Department concerning the collection of evidence and witness statements as a main factor in why this case took over twenty seven years to finally close. In the book, Detective Matthews noted the disorientation of the Hollywood Police Department when it came to taken down witness tips and information. While some of the detectives seemed organized, others assigned to the case would answer incoming calls randomly, jot information given by tipsters on scraps of paper or napkins or whatever might be handy, then hurry out on unrelated assignments without bothering to log their calls (Stanford Matthews, 201 1, p 26). At times it appeared that there was no sort of leadership organization. Even though Detective Hoffman was the lead investigator, he had never handled a high profile case such as this. When Otis Tool was subsequently arrested for having committed a number of there murders, he confessed to Jacksonville Police Department Detective Buddy Terry. Detective Terry contacted Detective Hoffman to advise him of the confession. From the onset, Detective Hoffman accused the Jacksonville PDP detective of feeding information on the Adam Walsh case to Tool. Detective Hoffman subsequently took numerous confessions from Tool but, it was as if he was trying to prove that Tool did not commit the crime. Detective Hoffman Went as far as to have Detective Terry removed from the case, accusing Detective Terry of supplying with the Adam Walsh case file because the two of them planned to write a book for money. In telling the story of the unprofessional between these two detectives it highlighted what appeared to be a common problem within the Hollywood Police Department. The Adam Walsh case was the first high profile case for Detective Hoffman. He was reluctant to work with other agencies in helping solve the case. Evidence of the murder weapon, car, victim’s clothing, and even an extortion letter were improperly handled. With Tool’s confession, the Florida State Attorneys office needed evidence linking Tool to the crime prior to an arrest warrant being issued. The strength of the evidence police roved to prosecutors is one of the most important factors influencing whether prosecutors file criminal charges. Thus, when police are able to secure tangible evidence and cooperative witnesses for the prosecution, the prosecutor is not only more likely to file charges, but is also more likely to win a conviction. (Number gradable, 2014, p. 251). The State Attorneys office was never made aware of any evidence surrounding the murder weapon or vehicle. Detective Hoffman went as far as to go on TV to claim that they found discrepancies in Tool’s confession. In cases such as this one, it would eave been best for Detective Hoffman to have given all the information to the State Attorney’s office and let them decide what could or could not have been utilized in the case. You read "Bringing Home Adam Book Critique" in category "Papers" The case of Adam Walsh involved several different police agencies. Anytime a question of jurisdiction is involved, it is important for agencies to work together and share information to solve the case. It is not uncommon for the Federal investigators to get involved in child abduction cases. In this particular case, Florida senator Paula Hawkins tried to get the FBI involved in the search for Adam Walsh. The FBI was reluctant to interfere n the case however. If Hollywood PDP was searching for a suspect somewhere out of state then the feds would be more than happy to lend a hand (Stanford Matthews, 2011, p. 149). In 1 988, FBI Deputy Director Alan Burgess advised that the Adam Walsh case had entered into the new nationwide database known as VICAR, the Violent Crime Apprehension Program. The FBI-VICAR became the national repository for violent crimes, collating data on homicides, sexual assaults, missing persons, and unidentified human remains (Stanford Matthews, 2011, p. 164). In 1988, the Walsh family received a letter from Tool confessing to the crime and ring to extort money in exchange for the location of Adam Walsh’s bones. The letter was given to Detective Hoffman and he filed the letter away citing a lack of physical evidence. Several years later, when the Walsh Family spoke to the Michael Sat at the State Attorneys Office, he advised that he was not aware of the letter. The book demonstrated Detective Hoffmann failure to share information based off what he considered relevant to the case. There also appeared to be do direct oversight from his superior. When John and Reeve Walsh realized that their son had been kidnapped, they used every source they could to find him. While child abduction is frequently sensationalists, exaggerated, and thus misunderstood, the myth of an epidemic does little to alleviate concern at the family level and widespread conventional beliefs about abduction have developed (Miller et al. 2008, p. 524). The Walsh family was thrust into the spotlight and their personal lives were exposed to the world. Allegations of infidelity and mob affiliation became, at one point, more important than solving the case. Despite this, John and Reeve Walsh managed to bring about change in the way information n missing children was shared amongst law enforcement agencies in the US. While the media tends to sensationalist news, John Walsh used th is to his advantage. He became the host of America’s Most Wanted and used this as an avenue to help other victims of crimes and bring perpetrators to justice. The authors detail just how the Walsh family used their own resources, as well as, outside resources to rally support in an attempt to locate their son. They first utilized search teams and even went as far as producing fliers that were distributed at every major U. S. Airport to passengers (Stanford Matthews, 201 1, p. 3). They worked tirelessly to aid in not only trying to find their son’s killer, but also other missing children in America. From their efforts came the passing of the Missing Children’s Act of 1982, the Missing Children’s Assistance Act of 1 984, the National Center for Missing and Exploited Children, and the Adam Walsh Child Protection and Safety Act. While the author does not detail the effectiveness of the legislation passed as a result of the Adam Walsh abduction and murder, it’s important to note the impact this case had on America. The legislation passed as a result of any type of heinous crime is usually roughs about as a result of public outcry and scrutiny. The Adam Walsh case invoked fear and anger from the community. Naturally the police were expected to solve the crime expeditiously and in a sense, make the streets safe again. According the National Center for Missing and Exploited Children, approximately 800,000 children are reported missing in the CSS and over 100 of these cases are stereotypical kidnappings. Meaning the child did not know the kidnapper or the kidnapper was an acquaintance. The first three hours are the most critical when trying to locate a missing child (â€Å"Key Facts,† 2014). Otis Tool was intent on kidnapping a small boy in the hopes of raising that child as his own. According to the research by Miller et unfairly abduction is more likely to have a criminal motive such as robbery or, more often sexual assault (p. 529). While Tool confessed to having customized Adam, there was no direct evidence to prove this. This study by Miller et al. , showed the difficulty in preventing unfairly abductions vs. family or acquaintance abductions. There have been studies regarding whether child abduction laws are effective in actually preventing crime or simply giving a ales sense of security. In a study conducted by Freeman and Candler (2009), the Adam Walsh Act (AWAY) was examined. The AWAY required states to standardize their registration and community notification practices by categorizing sex offenders into three-tier levels in the interest of increasing public safety (p. 31). The study examined whether or not the AWAY, as well as, other similar acts actually increased public safety. The results indicated that the AWAY failed to â€Å"increase the effectiveness of current registration and community notification practices. In fact, as indicated by the results of the rent study, the system actually decreases the ability of states to predict which sex offenders will sexually roofed and which ones will not† (p. 5). The legislation passed as a result of the Adam Walsh case was meant to create organization amongst the law enforcement agencies. Although it is natural for the media to sensationalist stories such as this, the main purpose was to at least create an avenue for law enforcement to share information with each other. The author detailed the numerous times when information should have been shared but was not. The Walsh family had not received word as to what evidence had been collected. Conclusion The book Brining Adam Home sheds light on one families struggle to find their son. The authors shed light on the reluctance of the Hollywood Police Department to work with other agencies to solve this case. The failure of the police to properly document evidence and witness statements caused this case to remain unsolved for longer than it should have. Behold, children are a heritage from the LORD, the fruit of the womb a reward. Children are God’s greatest gifts. The impact a child abduction has on a family can be detrimental and can forever impact that family. This case captured national attention and from that came a need to try and become more proactive than reactive when it came to child abductions. How to cite Bringing Home Adam Book Critique, Papers

Iron Age Hoplite Warfare and Democracy Essay Example For Students

Iron Age Hoplite Warfare and Democracy Essay Iron Age Hoplite Warfare brings about the First Democratic Societies in Archaic Age Greece, Following the Role of Monarchy, Feudalism and the AristocracyAs per the coverage in our course, in the Persian War, a Greek force from Athens set out to meet the invading Persian army at Marathon, and set them running. They were outnumbered by the Persians two to one, and the Persian army had been the biggest force the Greeks had ever seen. The majority of the killing took place while the Persians were hastily retreating to their ships. With only 192 dead, the Greeks reduced the Persian force by 7,000 men; however, the remaining 13,000 soldiers were still a sizable threat if they should sail down and enter Athens proper, and so the Greek army hastily moved back to their city. The question of how they did this feat might be explained by the Greek theme that any Greek warrior could take on ten barbarians, but for our purposes the interesting question is why their involvement with what they were fighting for was able to give them the push to oust the invading empire. I surmise that the involvement in the state militarily and thus politically for the Athenians, which amounted to the beginning of democracy as we know it. As it is suggested by the book title, The Roots of the Western Tradition dig deep down into the ancient civilizations. Greece is a unique, important and telling civilization to study for it reveals the beginning of systems in which we live that are still evolving. These Greeks had all voted together in assembly, and although assured by Persia that they could not meet the threat, they did not submit to a takeover. All the men who voted for war against Persia, an empire which frightened most other Greek Polis, including Sparta, from sending military aid to Athens, were the very men who would don their Hoplite armor, clash together shield to shield to form phalanxes, and defeat the Persians at Marathon. These men were motivated by their own interests and what they had to protect: their prospering Polis of Athens, and their financial and political gains that came from fighting for it. The Greeks enjoyed a sharing of power, which in their view, was the antithesis of the monarch style powers held by the Absolute Leaders of the Great Empires developing in the Near East. The Persian King was seen as being an ultimate master, and it was perceived that all of his subjects were essentially slave. This may not have been true to that extent, but certainly many men in the 20,000 force beaten at Marathon were not ethnically Persian peoples, and in many cases were people already conquered by the expanding empire. There is a clear difference between the motivations and wills of the soldiers that faced each other at Marathon. Until their great clashes with Persia, Greece had not fought with another great empire. Greece was just enough distance from the Ancient Empires arising in the Nile area and the Near East to have a very unique relationship with these monumental civilizations: they remained out of conflict with them, while engaging in the trade of goods, and just as importantly, engaging in cultural trade, whereby the Greeks were able to modify and use the developments of other ancient societies to their own advantage. Before these cultural links fostered the growth of civilization in Greece, the Greek language and identity had first come via the original Mycenaean Greeks, who had sacked Minoan culture, centered on Crete, and learned much from the Minoans; their culture differed from that of Crete chiefly in its emphasis on fortificationsThey adapted the Minoan script (Linear A) to their own very different language. The result was Linear B, which used a Minoan syllabary to express Greek words. (Hollister, 74) The arts learned in Mycenaean Greece from surrounding empires and cultures continued, though mostly not through violent conflict, as was the case with the Mycenaean devastation of Minoan civilization. Some would say the Greeks perfected these arts: from metal and weapon making, to the use of the Phoenicians system of alphabet and language, to the craft of writing, the Greeks perfected what other nearby early cultures were creating, by interacting and borrowing from them. This made Greece into the very unique, modernizing place it was as the Mycenaean period crumbled due to Barbarian peoples sacking the numerous city state kingdoms; Greece was soon plunged into a three hundred year Dark Age. Clearly, at some time during the Dark Ages the great landowning families the Old Aristocracy had stripped the kings of their power The Council or Officialsoccasionally summoned an assembly of the people (demos), all men.who probably made up the army and ask them to ratify some decision. Clearly the ordinary member of the assembly could hardly say no to anything that the Best People might propose. (Burn, 12) Out of gatherings of Dark and then Archaic Age oikos would rise a strong military and political leader, who was reliable for the defense of the community, the fear of Barbarian sackings being very real in this time period. As Greece was lifting out of the Dark Age and into the Archaic, these Paramount Chiefs, or Big Basileus (the terms Wanax and Korete were gone, leaving Basileus to signify, basically, a king), were becoming wealthier more and more, as Greece was getting far wealthier than it had ever been during the time of Odysseus. The Big Basileus engaged in a process known as synocism, a pr ocess of unification. The city state of Athens developed as the center of a unified Attica through peaceful means, while in Sparta synocism came about through a military process; in both cases, local Basileus were either killed off or incorporated into a new city state (lecture, 2/2/05) The nobility of the early Archaic age, known as the Agathoi, did not wish to see the Paramount Chief gain too much power through the accumulation of vast wealth, and thus they did everything possible to limit his powers, so that he could not become an absolute monarch. They accomplished this by dividing up the remaining powers of the king, such as leading the military, and acting as Chief Judge. The Sweet - Toothed Fairy EssayPlutarch. The Rise and Fall of Athens: Nine Greek Lives. 1960 Penguin Books. Ian Scott-Kilvert. Hollister, C.W. Roots of the Western Tradition. Grant, Michael. Civilization of the Ancient Mediterranean: Volumes I-III. 1988 Charles Scribners Sons. Hesiod translated by Richmond Lattimore. The Works and the Days. Theogony. The Shield of Heracles. 1978 The University of Michigan Press, Ann Harbor. Lectures.

Let There Be Light free essay sample

Consider the light for a long moment. Most people would say that they feel safer in the light. you can see everything, youre more aware of your surroundings. While most people grew up being scared of the dark, having to rush from the light-switch to the bed to escape the monsters that would come out of their closets, it would be far-fetched to think of someone being afraid of the light. The light is open, happy, warming. The first thing that people do in the morning—other than turn off that annoying buzzing thing that most people call an alarm-clock—is flick on the light. There’s nothing like a sunny day to brighten up a mood or save your electricity bill. There’s no secrecy; nothing waiting to pounce. A dose of good sunshine can bring light to any situation—unless you have a sun-burn. Darkness feels scary, untouchable without light. We will write a custom essay sample on Let There Be Light or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page No one wants to venture out alone in the black abyss, especially in an unfamiliar place. You don’t know what could be lurking around the next corner that you turn; you don’t know where your foot might fall. It’s not recommended or preferable to travel by night when there’s a luminous path to take by day. However, the same things that make light so attractive are the same reasons that most people voluntarily wander into the darkness. The often asked, slightly humorous question that has been asked summarized it all. â€Å"Does a light bulb emit light, or does it suck darkness.† Light seems to do just about that: remove the darkness. In the light, there’s no place to hide, no place to shield your imperfections. The fact that those around us seem blind to our vices provides us with a cloak of comfort. No one wants to venture to the darkness, remember? No one’s willing to brave the unknown for long enough to discover what we’re hidi ng. Most people, when they’re being truly honest with themselves, are afraid to expose their flaws, safely hidden in the shadows of their darkness. There’s more that you can get away with unseen in the blackness. With no illumination, there’s no truth, no way to prove that what you think exists really does. Humankind seeks out the light while living in the darkness. We are an imperfect race. As the saying goes â€Å"I’m only human.† We search out the flaws in others while constantly trying to cover up our own. But only when we step out into the light can we see each other clearly—virtues and vices. We must expose ourselves for the sake of truly knowing others.

Rates of Reaction Example Problem

Rates of Reaction Example Problem This example problem demonstrates how to use reaction rates to determine the coefficients of a balanced chemical equation. Problem The following reaction is observed:2A bB → cC dDAs the reaction progressed, the concentrations changed by these ratesrateA 0.050 mol/LÂ ·srateB 0.150 mol/LÂ ·srateC 0.075 mol/LÂ ·srateD 0.025 mol/LÂ ·sWhat are the values for the coefficients b, c, and d? Solution Chemical reaction rates measure the change in concentration of the substance per unit time.The coefficient of the chemical equation shows the whole number ratio of materials needed or products produced by the reaction. This means they also show the relative reaction rates.Step 1:Â  Find brateB/rateA b/coefficient of Ab coefficient of A x rateB/rateAb 2 x 0.150/0.050b 2 x 3b 6For every 2 moles of A, 6 moles of B are needed to complete the reactionStep 2:Â  Find crateB/rateA c/coefficient of Ac coefficient of A x rateC/rateAc 2 x 0.075/0.050c 2 x 1.5c 3For every 2 moles of A, 3 moles of C are producedStep 3:Â  Find drateD/rateA c/coefficient of Ad coefficient of A x rateD/rateAd 2 x 0.025/0.050d 2 x 0.5d 1For every 2 moles of A, 1 mole of D is produced Answer The missing coefficients for the 2A bB → cC dD reaction are b6, c3, and d1.The balanced equation is 2A 6B → 3C D

Can Human-Animal Chimeras Aid Medical Researches

Can Human-Animal Chimeras Aid Medical Researches Chapter 1 The Science behind the Biotechnology Chimeras rely on stem cells and their ability to differentiate into the necessary cells needed by the body. It is this feature of stem cells that allow scientist to culture tissue samples and eventually produce transplantable organs. The procuration of stem cells is the subject of a controversial argument as the methodologies of some variations raises several moral and ethical issues. Human Embryonic Stem Cells (hESCs) As the name suggests, this form of stem cells are derived from human embryos. Contrary to popular belief, these cells are not obtained from eggs fertilised inside a womans body; the embryos are usually donated for research purposes by In Vitro Fertilisation Clinics, with the consent of the donors. The embryos are then suspended in a culture medium ,mirroring similar conditions to that of a mothers womb, allowing the embryo to divide into a mass of cells known as the blastocyst. The cells within the blastocyst are usually referred to as totipotent stem cells. It is here that the first ethical issue arises. The beginning of life is said to be conception or fertilisation therefore this method of obtaining stem cells can be considered as taking a life without its consent. (U.S. Department of Health and Human Services, 2016) Another limitation of hESCs includes carcinogenic risk when the culture medium is altered in order to induce differentiation of stem cells to form specialised cells such as: heart cells, lungs cells, liver cells and nerve cells. If the wrong mix of proteins or hormones are added to the stem cells theres a potential risk of mutation of DNA resulting in the production of cancerous or faulty cells. Conversely, hESCs are more accepted in the scientific community as the production of it can be done at lower cost with much more efficient differentiation and the cells produced are within a suitable HLA spectrum. [1] (Pappas, 2008) Parthenote Stem Cells It is possible however to bypass the ethical and moral issues that hESCs present, as these issues only arise if the cell is post-fertilisation. Therefore, if stem cells are extracted from an unfertilised egg, then arguably life which begins at conception or fertilisation, has not yet begun, making the use of the stem cells less controversial. However, the ethical implications have not been bypassed altogether, as it can still be argued that stem cells from unfertilised eggs do still have the potential to make a living individual. Parthenogenesis[2] allows for the egg cell to be activated without the need for a sperm. Parthenogenetic embryos will develop to the blastocyst stage and so can serve as a source of embryonic stem cells. Parthenogenetic Embryonic Stem Cells (pESCs) have been shown to have the properties of self-renewal and the capacity to generate cell derivatives from the three germ layers, confirmed by contributions to chimeric animals (Department of Animal Science, Michig an State University, East Lansing, Michigan, USA, 2006) Induced Pluripotent stem cells The process behind iPSCs was a big medical breakthrough as it allowed somatic (body) cells to be reprogrammed into regenerative cells. The formation of iPSCs require the donor to undergo shave or punch biopsies, this procedure can be done under local anesthetic and is minimally invasive so the procuration of the adult cells poses no moral or ethical predicaments. The induction of pluripotency in adult somatic cells via proteins, will produce genetical and immune-histocompatibility matches thus, lowering the chance of rejection (if used for transplantation), this also reduces the need for the patient to take immunosuppressant which can result in a compromised immune response. But this form of stem cells comes with its disadvantages, as it is a new concept the cost of production is high. Therefore this process in its current state of development is economically viable for a large population size. Furthermore, the mechanisms behind how the reprogramming factors work are unknown, this pr esents the chances of mutagenesis[3], oncogene activation risk[4], and retroviral gene delivery[5] (Pappas, 2008) Chapter 2 Potential Uses of Animal-Human Chimeras in Therapeutics Vaccinations As of 2015, there are 36.7 million people living with HIV as per WHO and UNAIDS. (WHO, 2016). The field of vaccines for diseases such as Hepatitis-B and HIV (Human Immunodeficiency Virus) have taken a heavy toll in developing countries and have faced major failures. In the hopes of improving the current situation. Human-animal chimeras, developed with a humanized immune system could be useful to study infectious diseases, including many neglected diseases. These would also serve as an important tool for the efficient testing of new vaccine candidates to streamline promising candidates for further trials in humans. (Bhan, et al., 2010). Human hematopoietic stem cells, or in laymans terms, bone marrow cells, have the unique capacity of engrafting, greatly expanding, and repopulating immunodeficient mice, with virtually all different types of human immune cells; as shown by the image above. Humanized mouse models are produced via transplantation of CD34+ stem cells and/or implantation of human tissue into immunodeficient mice. Depending on whether tissue or CD34+ cells are used and the strain of mouse, this results in mice which have a part or a complete human immune system. (Garcia, 2016) This xenografted[6] mouse is then used as a disease model[7]. This allows scientists to better understand the mechanisms behind the disease, which results in a more efficient treatment plan for those who suffer from. Hepatitis-B. Another disease model being used are primates, these are considered to be the most accurate as we share a common ancestor. Additionally, primates have the closest metabolic conditions to humans. When this model was injected with HIV-1 (via IV), HIV-2 (via vagina) and SIV (via rectum) the results were advantageous as they provided useful information for vaccine and therapeutic studies. However, the cost of producing this model is very high and raises many moral and ethical concerns; furthermore, despite having some genetic similarities, primates do have different cellular and molecular markers and the time and course of infection could vary. Chimeras are also benefiting the treatment of Japanese encephalitis. This disease is a type of viral brain infection thats spread through mosquito bites, commonly found in South-East Asia. Although theres no cure for Japanese encephalitis, it can be prevented through vaccination, which is usually only available privately (NHS, 2016). A recently developed vaccine, which is an animal-human chimera which is a mouse brain-derived, inactivated JE vaccine (MBV). In order to evaluate its efficacy case controlled studies were carried out. A randomized double-blinded study conducted in northern Thailand, using JE MBV produced in Thailand, yielded an overall effectiveness of 91%. Another trial in Taiwan revealed an effectiveness of approximately 85% when two or more doses were administered. The effectiveness of the JE vaccine in Northern Vietnam was 92.9% efficacious. (Marks, et al., 2012). Control disease progression Another therapeutic use of animal-human chimeras is the development of drugs to aid in the treatment of known diseases.The drug called Rituximab, is a chimeric antibody which means it contains portions of both human and mouse antibodies mixed together. The drug was licensed in 1997 for the treatment of NHL (Non-Hodgkins lymphoma)-a form of cancer which causes B-cells to mutate and divide abnormally. The drug targets the CD20 receptor on B-cells as this receptor is located on the surface of the cell and it doesnt mutate, move inside the cell or fall off in the life cycle of the B-cell. The drug contains the variable domain of the mouse antibody, the portion that specifically binds CD20, along with the constant domain of human antibody, the portion that recruits other components of the immune system to the target-the B-cells and so after it is administered, and a large number of tumour cells are immediately destroyed and eliminated from the body. Rituximab is also used to treat advanced rheumatoid arthritis and it has also been part of anti-rejection treatments for kidney transplants (both involve B cells). The disadvantage only that the mouse antibody was unsuitable for direct use in humans and clinical trial results varied, likely due to the differing sizes of tumors between the patients, (Speaking of Research, 2017) Chapter 3 Potential Uses of Animal-Human Chimeras in Surgery The demand for organ transplantation has rapidly increased all over the world due to the increased incidence of vital organ failure. However, the unavailability of adequate organs for transplantation procedures to meet this growing demand has resulted in a major organ crisis. In 2014, 429 patients died while on the waiting list for an organ transplant- thats up to 3 patients a day. (Knapton, 2015). Currently, the government plan on changing the organ donation system to an opt out system, which hopes to promote organ donation and increase the availability of organs. The opt-out system presumes the donors consent unless the individual expresses a refusal to become a potential donor- allowing the donor to make a free choice (Abouna, 2008). As well as increasing obtainability of organs, it also increases the likelihood of more organs found within a suitable HLA spectrum. (Department of Health and Social Care and Cabinet Office, 2017). But it can be argued that this system of obtaining organs is seen as unfair as majority of organ donors must be recently deceased (excluding kidney donors) therefore the longevity of one persons life is at the cause of anothers death. (World Health Organisation, 2005) To prevent this choice being made, alternative solutions are being developed in order to aid the organ crisis-one of them being animal-human chimeras. Current research on stem cells have shown that they can differentiate into different cell types but cannot effectively produce usable tissues and organs as a culture medium cannot replicate the growth of an organ in a body. A recent breakthrough by the (Salk Institute of Biological Research, 2017) shows a pig-human chimera, which would be capable of making human organs. The research began by creating an interspecies chimera[8] consisting of a rat and mouse. They used a gene editing technology known as CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) to turn off the gene that makes the pancreas. They then inserted rat iPSCs which contained a pancreas gene into the mouse embryo. The result, when implanted into surrogate mouse mothers, was a fully developed mouse with a growing rat pancreas. This concept was then mirrored using pigs embryos and human stem cells; as pigs have similar organ sizes and developmental timescales as humans. Although this experiment had to be halted at 4 weeks of development due to ethical issues and the lack of consent- as the experiment was designed to prove it was possible, not to produce a human organ-we can safely assume that, if the development of the pig was allowed to continue, the pig would have a whole human organ inside it. Theoretically, this concept can then be implemented, producing specific human organs, eliminating the wait for a human donor and reducing the risk of organ rejection. Chapter 4 Potential Uses of Animal-Human Chimeras in Disease Modelling Scientific research is not always accepted as they require the use of controversial methods to obtain the necessary results. The methodologies behind creating chimeras have ethical and moral dilemmas primarily due to the use of animals. There is a large emphasis on animal welfare, although the use of animals as chimeras or in general medical research is considered very valuable as they help the medical community to better under the effects of treatments (drugs or otherwise) on living organisms. The matter still finds itself to be the subject of a very heated debate; as those opposing the use of animals animal rights extremists and anti-vivisectionist groups-believe that animal experimentation is unnecessary and cruel regardless of its benefits ergo the opposition want total abolition of animal research and if the majority supports this view then there will be severe consequences for scientific research. (Festing Wilkinson, 2007) On the other hand, the UK has gone further than most countries in regards to the ethical framework by introducing the Animals (Scientific Procedure) Act 1986 which regulates the use of animal research. Along with this, there is more and more public awareness as polls run by Ipsos MORI state that in 2005 64% of the population agreed with the use of animals in research if the research objectives are important and the animals experience minimal suffering and all alternatives are considered. (Department for Business Freeman, 2014) Another bioethical view that must be considered is `whether we treat the chimeras as animals or human? this arises as some chimeras require the altering of cognitive capacities. The chimeras are to be used to develop a better understanding of diseases such as Parkinsons and Dementia which affect 850 000 people every year (Anon., 2014) Unfortunately, the research is very slow due to moral views as some people regard this form experimentation a violation of human dignity and the order of nature as well as, the initial disagreement of using chimeras in the first place. (Hermern, 2015) Opportunely, there is some support for the use of animal-human chimeras as previous medical techniques that are widely accepted today allow the use of porcine, bovine and equine biological heart valves are implanted in those with cardiac valve dysfunction. Moreover, insulin extracted from porcine pancreas is routinely used with those with diabetes. And so, the prospect of a pig carrying a pancreas or liver of human origin should be justifiable. (Bourret, et al., 2016) Alternatives A lesser conventional view is the alternatives to chimeras, these methods do not require the use of animals to carry out medical research, which hopefully, should eliminate bioethical arguments. The issue that arises with this is the efficiency and viability of the results. The alternatives to chimeras include cell cultures, human tissues and computer models. Almost all cell types can be recreated in laboratory conditions and these can be coaxed to grow into 3D structures- miniature organs. Cell cultures have also been used to create `organs-on-chips which can be used to study disease mechanisms, as well as, drug metabolism. This form biotechnology has already managed to mimic the heart, lungs and kidneys. The goal is to be able to this for all organ systems. The idea is already aided in the development in the production of vaccines, and drug testing on top of aided research in the study of cancers, sepsis and AIDS. Human tissues can be donated by both healthy and diseased volunteers through surgeries such as biopsies, cosmetic surgery and transplants or via post mortem- such as brain tissue from a patient with Multiple Sclerosis to help better understand a large variety of diseases furthermore the tissues can make more effective models than through chimeras as they will contain only human DNA thus providing a more relevant way of studying human biology. Finally, computer models can be used to create virtual experiments based on existing information. Models of the musculoskeletal systems, heart, lungs etc. already exist. Inopportunely, this method isnt as effective as testing in vivo as the concept is very theoretical. (Anon., n.d.)

Hunger in America Essay Example | Topics and Well Written Essays - 250 words

Hunger in America - Essay Example This is significantly above the figure of Americans who go hungry daily. This shows the irony that underlines the food situation in America. Hunger is mostly associated to poverty. It is, therefore, natural that one should expect that the groups that are affected by hunger are the low class and the homeless, generally the social classes that belong to the low-income categories. This is, nevertheless, not the scenario as highlighted in the video Food For Thought, which shows the shocking reality that the middle class is adversely affected by hunger. Statistics support this with America recording 3.5 million homeless individuals. This number is significantly low as compared to the mammoth number of 35 million who are affected by the hunger issue. Though the number of middle-income individuals who suffer from hunger is not as large as that of the lower social classes, they make up a significant number of the number of the affected population. The reason cited from the problem is loss of income through unemployment, which jeopardizes individuals’ ability to access food (Donavan and Mash, p1). It is, therefore, imperative that America takes measures to curb this dire situation. This will involve putting measures in place that will reduce food wastage. Initiatives should also be put in place to distribute food and to empower individuals economically hence curbing

The Disparity In Sentencing In The Criminal Justice System Essay

The Disparity In Sentencing In The Criminal Justice System - Essay Example In the mid 1970’s a remarkable burst of reforms (Walker, p. 112) were introduced whose main concern was about disparity and discrimination in sentencing. The indeterminate sentence was the main focus of the reform efforts. The sentence in which the offender received a minimum or maximum sentence and the date of release was decided by the parole board is known as indeterminate sentence. Under such sentencing the judge was to decide about the punishment by not only looking at the crime but also looking at the circumstances and the potential for rehabilitation. On the basis of this judgment the parole board was to decide the date of release. Discretion was distributed amongst not only to the justice officials but also the parole board. The result of this process was: "A system of sentencing in which there was little understanding or predictability as to who would be imprisoned and for how long" (Bureau of Justice Assistance, p. 6). Both the liberal and the conservative boards cha llenged the reforms. The liberal presented an argument that the intensity on of the punishment should not rest with the criminal officers or the parole board because they may have racial issues. While the conservative board argued that the punishments given to criminals were too lenient. Their arguments bolstered by the findings of research demonstrating that most correctional programs designed to rehabilitate offenders and reduce recidivism were ineffective (Martinson).

A view from the Bridge Essay Example for Free

A view from the Bridge Essay Eddie: Listen, you been givin me the willies the way you walk down the street, I mean it. The relationship between them is that of a father and a daughter. The tension increases in the relationship when Eddie hears about Catherines new job. Eddie: .. plumbers; theyll chew her to pieces if she dont watch out. Eddie is overprotective about Catherine especially when she has a new job. However, then he allows her to take the job. He gives Catherine some advice. Eddie: . dont trust nobody. He calls Catherine Modonna this is a religious overtoues. He worships her. If I was directing the play I would make that scene a bit intense and make Eddie feel hurt when Catherine has got a new job but Catherine and Beatrice dont see it. The tension grows in the relationship when Beatrices cousin, Marco and Rodolfo arrive. Eddie becomes jelous of Catherines interest in Rudolfo. Rudolfo and Catherine have gone to the Parmount and they come home having enjoyedtheir evening. Eddie tells Rudolfo to go into into the house because he wants to speak to Catherine. Eddie tells Catherine that Rudolfo only likes her so that he can get a passport. Catherine disagrees with this and refuses to believe Eddie. Eddie: Katie, hes only bowin to his passport. I think that Eddie is using this to come between them because I think Eddie has feelings for Catherine and he likes her. If I was the director I would bring more tension into this scene and create some kind of argument between Eddie and Rudolfo. Eddie comes home drunk and sees Rudolfo coming out of Catherines bedroom. He becomes angry and upset. He tells Rudolfo to leave the house, but Catherine says no and she is the one who will be leaving the house. In that scene Eddie kisses Rudolfo to show that he is not straight(gay). Catherine: I think I cant stay here no more. Im sorry, Eddie. The relationship between Eddie and Catherine is getting worse and more tense. Catherine is very angry with Eddies anti social behaviour. Catherine tells Eddie that she is going to marry Rudolfo. Eddie tries to tell her that she is too young and that this is the first guy she has met. Eddie doesnt want Catherine to go ahead with the marriage. But you never knew no other fella, Katie! How could you make up your mind? If I were to direct this play, I would put more action into this scene and a little argument about the wedding. The final relationship which I am going to explore is the one between Catherine and Beatrice. Beatrice loves Eddie and wants to respect Eddie, but Catherine comes in her way. Beatrice understands that Catherine is growing up and she is not a baby, but Eddie is being over protective of Catherine. Beatrice becomes more certain that Eddie is heading towards disaster. Eddie: Beatrice, shes a baby, how is she gonna know what she likes? Beatrice: Well, you kept her ababy, you wouldnt let her go out. Beatrice tries to reason with Eddie. She tries to tell him that hes being selfish. Catherine try to affect Eddie. Catherine is confused and innocent throughout the play. If I was directing this scene I would create a havoc between Beatrice and Eddie and their relationship would break up. I think that Beatrice is jelous of Catherine but she is doing the right thing. She tries to push the girl out to work so that she doesnt come into the relationship between her and Eddie. Beatrice is aware that Eddie some sexual desire for Catherine but she doesnt blame Catherine for this. She tries to tell Catherine to move on with her life and she does this by standing up for her when she found her first job and when she is going out with Rodolfo. Catherine doesnt encourage Eddie purposely. She is not deceptive. Catherine takes Beatrices advice to move on with her life. Beatrice: You still walk around in front of him in your slip. Beatrice: well you cant do it. Beatrice tells Catherine that she is not a baby and she shouldnt walk around in her slip when Eddie is shaving his underwear. She tells her to go on and marry Rodolfo. Beatrice is doing the right, but inside I think she feels jelous of Catherine. Beatrice was happy when Catherine announced her engagement. Beatrice is ready to attend the wedding but Eddie doesnt want to. Catherine: Im gonna get married, Eddie. So if you wanna come, the wedding be on Saturday. I would direct this be instructing Beatrice to shout at Catherine, teaching her to get on with her life. I would tell Catherine to actas if she is confused why Beatrice is shouting at her. In conclusion, I think Arthur Miller has done well to show the relationships between the characters. He has used different types of techniques and he has been succesful in doing this. Relationships are a major factor in the play because actions come from the characters and their prejudice attitudes etc. Miller shows conflicts, love and arguments through characters. I think the main point of the story is it shows if relationships dont work, it leads to death and conflict. Show preview only The above preview is unformatted text This student written piece of work is one of many that can be found in our GCSE Arthur Miller section.

The Parthenon Essay -- essays research papers fc

The Greeks had an eager individualistic strain that led them to high levels of creative thinking in art, science, and literature. They were by nature sensitive to beauty and made its creation and enjoyment an important and necessary part of their lives. The Parthenon is a beautiful monument noted for its perfect simplicity of design and the harmony of its proportions. 1 From the architecture, to the sculpture, to the history of this great monument the Parthenon remains a masterpiece. The Parthenon is an ancient Greek temple dedicated to the goddess Athena Parthenos (Athena the Virgin), on the Acropolis in Athens. 2 Most Greek cities had an acropolis (meaning "high city" in Greek). The Greeks developed three architectural systems, called orders, each with their own distinctive proportions and detailing. The Greek orders are Doric, Ionic, and Corinthian.3 The Parthenon architecture is of the Doric order. It is the earliest and simplest of the Greek architectural orders. The Parthenon's columns give an impression of graceful solidity and power. It was built from 447 to 432 BC, under the leadership of Pericles. The Parthenon was a rectangle marble temple measuring about 102 by 230 feet. It had 17 columns along each of its sides and 8 columns on each end. 4 The distances between the columns of the Parthenon vary mathematically so that when viewed from a distance, the columns reflected optical distortions. For example, a column that was perfectly straight wou ld look like...

Happy Endings by Margaret Atwoods Essay

Every literature tries to make a specific point. A good writer always associates her opinion, ideas and thoughts in her or his masterpiece. Some produce literature are purely for entertainment stressing that life is funny and humorous, some include many ironies highlighting that life is complicated and hard to understand, some literature especially those classics are for the purpose of political movement portraying the kind of values and morality the society has, some are for the purpose of religion and spirituality and some literature was made to emphasize creativity or unconventional way of creating a literature. Happy Ending by Margaret Atwoods  was used by her to portray what makes a literature genius, more authentic and interesting. Most readers consider a literature ‘nice’ if the ending satisfies them and satisfaction is always in connection to happy ending, giving a social justice to the characters’ predicaments especially of those protagonists. However Margaret Atwoods illustrates in her short story that it is not the end of the story that is important but how well the beginning especially the middle were structured. How and the characters’ circumstances happened are more significant than what happened in the end. The creation of â€Å"Happy Endings† by Margaret Atwoods is not so much about the how the story ends. The writers give different options on how the story might end and the various possibilities of John and Mary’s love story. The story is divided into six possible life scenarios of John and Mary’s love story. Atwood sums it up in her concluding remarks. â€Å"John and Mary die. John and Mary die. John and Mary die. † On plot A, it offers the classic boy meets girl story that demonstrates the usual â€Å"live happily ever after† ending. This is the type of story that most readers wanted to believe in. However the succeeding version breaks away from the cliche of fairy tales, introducing a more realistic perspective in the midst of dominance, tragedy and cynicism. The point is that the writer compels and reminds us to the basic reality of life, that every body dies and that everybody fades away- that is the real and ultimate ending for every human being. Margaret Atwoods is particularly stressing that the readers should not seek the satisfaction on the ending because the ending will not help them to relate about life because all lives has the same ending. In order to fully embrace the importance of literature, one must critically meditate on how and why the characters commit a particular action and decision. The story is not found in the ending but it’s in what we do while we are alive that gives meaning to our existence. Literature for Atwoods has no ending if the characters did not die. The author’s belief that fiction has many beginnings and middles, but only one eventual ending. Margaret Atwoods suggests that we can do nothing about our mortality but we can precisely do something about the quality of our lives. Atwoods says that life is a continuous and never ending journey that there is no concept of happy ending as long as you live in this world. You might end up marrying your dream person but that doesn’t already mean and guarantee that your life is a happy ending; no one knows what will happen next. Every existing being has only one ending and that is death. This story also takes us through our childhood preconception about how love and life is supposed to turn out based on what has been written in fables and fairy tales. As human being grows older, they slowly realize through experience that most fiction fairy tales ending is unattainable. Obviously Atwoods opens up with various settings, different versions and opportunities that are grounded to reality. Atwoods may also want to redefine the stereotypical characterization of men and women and to the readers who readily accepts such gender typing. Most love stories always employ women as a weaker sex who is incapable of themselves most of the time. But in this story, Atwoods introduces the different facets of women who are both capable of vulnerability, unselfish love and extraordinary strength just like men. Atwoods employ both the weaknesses and strengths of Mary and John from those various possible plots. It challenges the writers on where to proceed next from the typical and conventional creation of love story with a more realistic endings and scenarios. Writers must not stay to those predictable stories that will not help the readers much. Writers must be more realistic in portraying themes so that the readers’ life will not lead to destruction. Typical fairy tales as we all know has been destructive, it makes the readers detach to reality, hoping unreasonably that everybody has a happy ending. Hoping of something unattainable will corrupt one person and eventually the society.

Muslim Empires Essay

The Ottoman Turks consisted of Turkic-speaking nomadic people who had spread westward from Central Asia in the ninth, tenth, and eleventh centuries. They were located in the northwestern corner of the peninsula, which allowed them to expand westward and eventually take over empires between the Mediterranean and the Black Seas. The sultan was the supreme authority in both a political and a military sense. Administrative and military power were centralized under the bey, who was only a tribal leader, tribal law was before Muslim law. The Ottoman authorities were Sunni Muslims. The sultan assigned duties to a supreme religious authority, who then maintained a system of schools to educate Muslims. There were some who believed in Sufism or other doctrines, but the government allowed it as long as they were still loyal to the empire. Non-Muslims had to pay a head tax since they were exempt from military service. The Ottoman Empire was divided into four main occupational groups: peasants, artisans, merchants, and pastoral people. Shah Ismail founded the Safavid Dynasty. The Safavids was a mixed society like the Ottoman Empire; majority of the population were Iranian. They used the Shi’ite faith, and Shi’ism was declared the state religion. Like the Ottoman’s sultan, the Safavids had their shahs who would check up on their people. This empire was not as wealthy as the Ottomans and the Mughals. Their greatest area of productivity was in textiles. The founder of the Mughal Dynasty is known as Babur. Ruling of the dynasty was passed down from Babur to his son, Humayun, and then to his grandson, Akbar. As emperor, Akbar didn’t just focus on the views of Muslim but also gave Christian views a chance. He later formed a new type of worship called the Divine Faith, which combined characteristics of different religions. He believed in having a harmonious society, which meant each individual and group would play their assigned role and contribute their part to society. This dynasty was the last of the great traditional Indian dynasties. All three of the empires were Muslim, and they all displayed an impressive capacity to create and run a large empire. The Muslim World was protected by the military and political abilities of these empires. Unlike their European counterparts, these empires continued to thrive.

Battle between Husband And Wife essays

Battle between Husband And Wife essays A Review on the First Part of was D.H.Laawrences first major novel.His only major novel,some would say.I have finished reading it during the winter holiday.For I am not quite sure that I understand the novel enough to depict the complicated relationship between Paul and his possesive mother,so I would like to pay attention mainly to the Part One of the novel in this review,especially the battle between husband and wife . At the first glance of the book,we find Mr.Morel a coal miner in turn-over-the-century Britain,lives a life of drudgery ,anger and desperation.He takes his frustrations out on his wife Gertrude.But with a deeper look into the internal subtleties of marital relationship.We can see it is both the husband and wife who are suffering and it is the vast differences in the social backgrounds divide them. Walter and Gertrude encountered in a local dance.Lets discuss the social background of the two involved first.Gertrude grew up in a steady lower-middle-class family with a strong work ethic and pride in its self-sufficiency.She inherited most of his fathers rigid moral and religious beliefs though she also has her mothers gentle,humerous streak.As a practising Congregationalists of her day,she disapproves of dancing,frivolity and drink,which Walter is a man of action rather than words.They were both attracted by each others difference at their first meet.Gertrude was fascinated by Walter who seemed as a mysterious stranger from another planet to her,rough and vigorous.He,in turn,arouses a passion in hera woman with class ,culture and education.They married and shared a brief happy union.Then follows the ever-lasting battle. The first dispute between them was when Gertrude found that they did not own their house. To her puritanical mind,the debt is not only shameful but sinful.In her eyes,it is a ...

Why should I be selected for this scholarship Essay

Why should I be selected for this - Scholarship Essay Example I am a single parent with two children; the children require my emotional and financial support as well as the normal upbringing. Background is another significant for me. My parents do not have college education and I am the first one in the family to go to college. Am therefore basically coming from a background that has not known the importance of education and as such I have to struggle on my own as there is not even one person to guide me. I have personally interacted with people who have benefited from education and now know just what my goal is in pursuing professional studies. I will overcome the obstacles above by striking a balance between studies and caring for my two children. I will also not allow my background to destruct my focus on achieving professional qualification and in fact will use my education to serve as a role model to other members of the family. This scholarship will therefore go a long way in enabling me not only complete my studies but also contribute to the betterment of

Assessment Instrument for Assessing Autism Term Paper

Assessment Instrument for Assessing Autism - Term Paper Example This suggests that a system for eliciting parental views should be built into any assessment tool for autism, and that extra language support for non-native speakers of Spanish or English should be provided to ensure that this group is not left behind. There is a wealth of knowledge that parents can contribute if a method can be found to elicit their views and record them in a consistent and comparable way. Parallel to the input of parents, there is the standard procedure of child development screening carried out at specified stages during health and educational interactions. The BRIGANCE Standard Diagnostic Comprehensive Inventory of Basic Skills (Glasgoe, 1999) was first devised in the 1970s and has been refined and extended since then to cover a wider age range and a more clearly defined set of criteria. In its present form, it is widely accepted as a good standard instrument which allows both effective local assessment and wider collation of results across the United States which can be used to build a picture of changes in the patterns of child development as they emerge. This test certainly does pick up significant numbers of cases for further investigation but it is not specifically designed to screen for autism. Parents and broad-based standard testing are therefore a crucial first line and very basic level of screening which are effective for the majority of children. A screening instrument in the UK for very young children around 18 months of age called the â€Å"Checklist for Autism in Toddlers† or simply â€Å"CHAT† has a series of yes/no questions. The questions in section one are general, such as â€Å"does your child enjoy being swung, bounced on your knee† and these are answered by the parent.  

SLP 5 HRM 403 THE GRASS IS NOT ALWAYS GREENER CAUTIONS ABOUT Essay

SLP 5 HRM 403 THE GRASS IS NOT ALWAYS GREENER CAUTIONS ABOUT INTERNATIONAL GROWTH - Essay Example Fred should also employ collaborative means of dealing with the employees; in essence, he should develop interpersonal relationships and bring together the cultural groups and teach them to collaborate for the benefit of the company (Cuevas et al., 2011). That way it is cheap to create proper business interactions and attain a collaborative workforce. Another important step is to establish warm relationships with his co-workers within and outside the office as it is done in the Japanese culture. With regards to his family, he should take time to deal with issues facing the family and engage them in dealing with the cultural challenges they are facing as well as encourage his wife to exercise patience. Fred should also find a job for his wife in Tokyo so that she feels productive. Apart from the above steps, Fred should conduct the following; He should develop avenues of communication, release control and ask for the response from workers. Also, he may share corporate principles with Japanese clients and preserve harmony instead of conflict. It is clear that the pre-departure training across the cultures is pertinent and could be a significant step towards solving the problems facing Fred. Both Fred and his Wife should have had the pre-departure training as it would first inform them of the challenges awaiting them in Japan. The training would also provide Fred and His family with the proper ways of handling the challenges they would encounter. In this regard, Fred would be aware of his difficulties and on the other hand Jenny would also be aware of family challenges; therefore, each one of them would easily tackle the issues without involving the other party. Family problems would not concern Fred because Jenny would be able to deal with the occasions as they come single-handedly (Cuevas et al., 2011). 3. If a firm does not want to invest the capital and resources required to train an employee about other cultures

Natural disaster Essay Example | Topics and Well Written Essays - 750 words

Natural disaster - Essay Example The disastrous effect of the earthquake in Haiti needs quick management and attention from the rest of the world and proper utilization of all the methods accessible for restoration of the country are important to save people in this part of the world. An article in the New York Times was published in January 2010 bearing the title â€Å"Thinking about a New Haiti†. This article provides an insight into the destruction that struck Haiti as a result of the earthquake. It explains the fact that many people lost their lives in this disaster and the infrastructure in the country became destroyed and people became stranded. It puts forward the fact that counties of the world including United States and Canada have started negotiating for aid and help to redevelop this country into a New Haiti. The author has also presented suggestions for quick recovery which include the utilization of the sources which the country has efficiently, spreading the people around the country to small towns and villages for the promotion of jobs and better living as well as the development of the roads and other structural requirements of the country. Foreign help and assistance from Haitians who are settled in different countries has also been put f orward in the article. â€Å"Thinking about a new Haiti† by the author is a subject that needs to be brought up and has been explained by the author perfectly. He has used language to create a proper connection between the Old Haiti and provided an insight into the development of the New Haiti. The author explains the poor condition of the people in a clear manner with these words, â€Å"In old Haiti there is still mostly horror. It is a nation of the homeless and maimed. Despite a stunning global surge of aid, many survivors still lack water, food and tents. â€Å"With this explanation he puts forward the importance of the aid that the Haitians require. The author coordinates his article in a manner to explain to

Glycolipids: Function and Structure

Glycolipids: Function and Structure Introduction Marine fungi are saprophytic or heterotrophic form of filamentous spore forming eukaryote microorganisms are extensively lives in the marine or estuarine ecosystem. The characterization and diversity of the marine fungi can be studied by the direct observation of morphological structure and next generation sequencing. Taxonomically characterized marine fungi are belongs to either facultative or obligate forms. Facultative forms are originally sourced from terrestrial or fresh water region but they are able to colonize and adopt with the marine habitat and the obligate are extensively live in marine ecosystem (Kohlmeyer and Kohlmeyer, 1979). The fungi are extensively reported for the several biotechnological applications industrial utilization in enzymes, natural products and agriculture biocontrol etc. The marine fungus are taxonomically distinct (Jones et al., 2009), saline tolerant (Jennings, 1986), special biochemical properties (Damare et al., 2006). Interestingly, the marine fungi have the novelty than the obligate fungi and attracts in applications of omics (Damare et al., 2012). Generally, marine fungi can be isolated from the nutrient rich substrata such as decaying wood (harbour), coral reef (Le Campion- Alsumard et al., 1995), seagrases (Thirunavkkarasu, 2011) and mangrove ecosystem (Saravanakumar et al., 2012) and deep sea soil (Damare, 2007) are enhance distinct diversity of the obligate fungi (Sridhar, 2005). Among the marine substrate, mangrove is an second largest source for the isolation of obligate marine fungi (Ragukumar 2004). However, the biotechnological application of marine fungi differs with the terrestrial fungi due to their environmental adaptations and distributions. Many research focus on biotechnological utilization of natural products, enzymes, biocont rol, bioremediation, fuel conservation, waste management by using the marine fungi. A lot of structurally and pharmaceutically novel metabolites, isolated from marine fungi. However, this article focuses the glycollipids from the marine fungi and their properties, biological functions and applications. Glycolipids are a structurally very heterogenous group of membrane bound compound present in all living prokaryotic and eukaryotic organisams to human cells. The term of â€Å"glycolipid† is a compound contains one or more monosaccharides glycodidically linked in to a lipid (Brandenburg and Holst, 2005). Glycolipids are an essential constituent of cellular membrane and have the remarkable biological functions of cell aggregation or dissociation act as receptor of accepter to provide the contact. Several glycolipids has important role in immune system. Fungal glycolipidomics The glycolipids are interesting group of the compound occurred in cell wall of animals, microbes and plant sources (Pinto et al., 2008). The fungal glycolipids are composed of a sugar units usually glucose and galatose, hydrophobic ceramides, C19 sphingoid, C-9 metyl braches and unsaturated linkages with hydroxyhexadecanoic acids (Pinto et al., 2008). Glycoconjugates in fugal cell wall Glycoconjugates are composed of glycoprotins, peptides, glucons, polysaccharides, phosphoric acid, phospholipids, nitrogen and glycolipid molecules and found in the cell wall. Among the defining characteristics of fungal is cell wall complex architecture. Fungal cell walls are substantially thicker than bacterial cell walls and normally make up 10-30% of the biomass. They are freely permissible to small molecules and solute transport system and signalling receptors remains in cell membrane. A different cell wall found in the fungi comparing to animals and the role of these walls includes osmotic support, selective permeability and interaction with environment (Conzalexz et al., 2009). Fungal walls consist of covalently cross linked polysaccharides of ÃŽ ²-glycans and Chitin and several polysaccharides are covalently cross linked through glycosidic bonds (Pinto et al., 2008). Fungal glycolipids exterior Generally, the glycolipid molecules are found in cell membrane of all eukaryotic cell membranes, are contain the sugar called as glycolipids besides biologically produced biosurfactants are called as glycolipids. However, all type of glycolipids are biosurfactants but not all the biosurfactants are glycolipids (Mukherjee et al., 2006; Khopade et al., 2012). Simplest glycolipids contain the one or more sugars (Fig.) and complex glycolipids such as gangliosides contain a branch chain with several sugars. Cell membranes of the fungi have the many types membrane and are assembled from four compounds such as (i) phospholipids molecules, (ii) transmembrane proteins, (iii) inerter protein network, and (iv) cell surface markers are not identical. The glycolipids are formed in the cell wall of fungi by glycosylation in endoplasimic reticulam (ER) membrane sections and transfer the Golgi complex followed by plasma membrane (Fig). These add the sugar molecules chain to lipids called the sugar c oating lipids that extents the outside of fungal cells and differences were identified in glycolipids among fungal species and used as cell surface layer or marker besides glycolipids are also compound of the fatty acids contain carbohydrates, and nitrogen not phosphoric acids includes the certain compounds of the gangliosides, sulfolipids and salfatids (Pinto et al., 2008). The glycolipids are a marker for the cell identification of cell surface changes and are serving as fundamental building blocks of fungi, energy molecule or store, component of membrane constituents, signal molecule to interact the environmental compounds in through outer matrix, lectins, growth factor, and a potential factor of pathogenesis and immune responses (Hakomori, 1990; Springer and Lasky, 1991; Pinto et al., 2008). Moreover, the detail mechanism of role and properties of the glycolipids in fungus remain unclear. Marine fungal glycolipids Research on glycolipids from the marine resources has expanded the due attention due to its potential novelty in biotechnological applications. Muralidhar et al., (2003) have been reviewed the glycolipids from the marine resources such as algae (Lo et al., 2001), microorganisms: bacteria (Batrakov et al., 1998), fungi (Abraham et al., 1994), yeasts (Zinjarde and pant, 2002), actionbacteria (Kokare et al., 2007), sponges (pettit et al., 1999), gorgonians (Shin and Seo, 1995), sea anemones (Sugita et al., 1994), bryozoans (Ojika et al., 1997), tunicates (Loukaci et al., 2000), marine annelid (Noda et al., 1992), star fish (Sugiyama et al., 1988), sea cucumber (Higuchi et al., 1994), sea urchin (Babu et al., 1997) crinoids (Arao et al., 1999), molluscs (Yamaguchi et al., 1992), and marine crab (Asai et al., 2000). In terrestrial Fungus, in general yeasts have glycolipids as major constituents and are not the major compound in more fungal species. However, a high Glycolipids content of 11-16% of total lipids in Blastocladiella emersonii, the major compound of glycollipid is GalDAG and Gal2DAG (Mills and Cantino, 1974). The 61- 48 % of glycolipids is found in mycelia of Macrophomina phaseoline and the lower in the sclerotia (14-62%). However the glycolipids concentrations varied according the constituents of fermentation medium. The major compound of the fungal glycolipids identified as GalDAG and Gal2DAG based structural characterization. Further the major glycolipids of fungi is glycosphingolipids and D- glucosylceramides (Weete, 1980). Galactocerebrosides has been found in fungal species, of Aspergillus miger, C.utilis and S. cerevisae (Wagner and Zofcsik, 1969). Besides the fungal species Fusarium lini, Phycomycetes blakesleeanus and mushrooms are known to produce the glycolipids (Weiss et a l., 1973). Subsequently, the glycolipids are widely studied from Torulaspora delbruecki , Saccharomyes cerevisae, Candida glabrata, Kluyveromyes yarrowii, F. pedrosoi and K. polyporus (Saito et al., 2006 ; Pinto et al., 2008). The long chain sphingadinene has been first reported from Aspergillus oryzae (Fujino and Ohishi, 1976) and subsequently from Schizophyllum commune (Ballio et al., 1979), Fusicoccum amygdale (Ballio et al., 1979)), Clitocybe geotrope and Aspergillus fumigatus (Villas Boss et al., 1994), C. nebularis (Fodegel et al., 1986), A. niger(levery et al., 2000), A. versicolor (Walenkamp et al., 1999), Candida albicans (Matsubara et al., 1987), Acremonium chrysogenum (Sakaki et al., 2001), Cryptococcus neoformans (Rodrigues et al., 2000), Colletotrichum gloeosporioides ( de Silva et al., 2004), Fonsecaea pedrosoi (Nimrichter et al., 2005), Hansenula anomala (Ng et al., 1977), Fusarium sp. (Duarte et al., 1998), Histoplasma capulatum (Toledo et al., 2001), Kluyeromyces wa ltii (Takakuwa et al., 2002), paracoccidioides brasiliensis (Takahahi et al., 1996), Magnaporthe grisea (Koga et al., 2006), Pichia pastoris (Sakaki et al., 2001), Saccharomyces klyuyveri (Takakuwa et al., 2002), Pseudallescheria boydii (Pinto et al., 2002), Termitomyces albuminosus (Qi et al., 2002) Sporothrix schenkii (Toledo et al., 2001). In marine fungi, very few studies are available on glycolipids of marine fungi (Table.1); the marine white rot marine fungi Nia vibrissae is producer of glycolipids with inhibitory activity, the binding of endotoxin Lipopolysaccharide (LPS) to human endotoxin receptor (Helmholz et al., 1999). Marine fungi Gliocladium roseum KF-1040 is a producer of Roselipins can inhibit the enzyme diacylglycerol acyl transferase (Omura et al., 1999; Tomada et al., 1999; Tabata et al., 1999). Glycolipids derived from marine yeasts Calyptogena soyoae, Yarrowia lipolytica are effective on degradation of hydrocarbon (Zinjarde and pant, 2002; Konishi et al., 2010). Glycolipids synthesised form filamentous endosymbiotic Aspergillus ustus has the significant antimicrobial activity (Kiran et al., 2009). Several marine fungus such as Penicillum sp. F23-2 (Sun et al., 2009), Linincola laevis (Abraham et al., 1994), Fusarium sp (Li et al., 2002) and Microsphaeropsis olivacea (Keugen et al., 1996) are significa ntly produced the glycolipids with unknown application.

A Defining Moment In High School Athletics Essay -- Personal Narrative

A Defining Moment In High School Athletics I was a part of something my senior year that not many High School students will ever experience. It is one of those things that I will tell my grand kids about in years to come. The 2002 Fort Defiance Wrestling Team had a winning season with a perfect record. Our accomplishments as a team and as individuals will be in the records books at Fort Defiance High School, Virginia. Students athletes who play sports in school have dreams for their and themselves. One of these dreams is being exceptional enough to make it to the trophy case. We made it! The hard work, long practices, and discipline within the sport and us paid off. We were the first wrestling at Fort Defiance to have a perfect season. The wrestling started training for the perfect season the first Monday after Labor Day it was the 9th of September 2002. The day was very hot and muggy. The temperature outside was about 95 degrees. We all knew that practice was going to be to very tough. We were going to regret not working out all summer. Since wrestling the team camp had been about two months earlier, and that was the last time we had trained. We knew that we were going to pay a huge price for not listing to our coach and staying in shape. The first couple of weeks were tougher than I imagined. The training went on for the next two months until the season started. Most people looked forward to the end of the school day when it is time t go home. However that was not the case for me during wrestling season. My fun was just starting. Everyday we ran two miles to start with, then a couple of sprints. Then we would go into the wrestling room and stretch do run downs, which is were you do 15 push-ups then 15 sit-ups then 1... ... a wrestler, its not for all people you either love it or u hate there is no in between, the sport is too hard to just do it for fun. Wrestling demands many things from a person and would not be a sport for everybody. There have been many times that I have questioned myself in the sport. It’s not only the physical aspect that is hard it is the mental aspect as well. Situations like not eating when you come home from practice so you can make weight. It’s waking up two hours before school starts so you can run to make weight. It’s believing in yourself when no one else does. It is a deep desire from within to be the best that you can be. My Wrestling experience in high school has shaped my life and made me the person I’m today. Being a wrestler is tough, but I’m thankful I had the experience. The lessons that I learned and the friendships made will carry though life.

Li & Fung

A critique of the case â€Å"Li & Fung (A): Internet issues† is presented below in light of the following two key methodologies: SWOT analysis Porter's five forces model A SWOT analysis of Li and Fung: Strengths of the firm Reputable name and branding. Well informed and educated management Tightly integrated supply chain management with client base. Established decentralized management style Ability to operate in both hard and soft markets. Existing internal capital Successful acquisition strategy (bought suppliers and competitors). Flexible and interactive design process. No inventories to manage. Weaknesses Lack of initial knowledge on developing an e-commerce B2B profile. Lack of qualified personnel and subject matter experts to implement such a large undertaking. Poor information gathering and research prior to adopting the B2B portal strategy Insufficient knowledge about the behavior of SMEs in similar portals The initial plan of developing a B2B portal was based on the old economy model, change was not sufficiently accounted for. Opportunities The internet is a true enabler to incorporate a more streamlined supply chain management system. Allow customers to be able to be an intricate part of the design process up to the point of product manufacture. Allow SMEs to participate in product procurement while enjoying a smaller commission rate. Ability to establish a business plan to develop markets in which surplus products could be sold (Electronic Stock Offer – eSO) Threats Phasing the â€Å"middle man† out of the trading scheme is a risky strategy and an attempt to alter an existing market mechanism. Possible loss of key employees to other Internet companies through the promise of greater wage compensation for newly acquired skills. Fear that an online company would acquire or partner with an old economy trading company, becoming an overnight competitor. If the technology was outsourced, then the company could become dependent on that outside company for their IT needs especially when an upgrade was needed. The possibility of outside companies being able to access proprietary information, strategy, or the complete Li & Fung business model. Exposing the business to a new business environment with insufficiently prepared change strategies Service quality issues in an area where the firm has never operated before could tarnish its reputation and result in loss of value The new e-commerce endeavor made some of their larger customers nervous in that they were afraid that Li & Fung would be compromising their business by working with their direct competitors. Porter's five forces model: Traditional Rivalry – most of Li & Fung’s rivals have been acquired. Bargaining power of suppliers – sold raw materials to suppliers at a premium. Bargaining power of buyers – efficient and considered high value. Threat of new entrants – low threat of entry. Threat of substitute products- possibilities of threat in this area. Business Concept Li & Fung is a long standing Hong Kong based company that that has evolved from an export trading company to a coordinator of value-added services across the entire supply chain in a global, open manufacturing environment. They assess the clients’ product and delivery needs and orchestrate supply, manufacture and delivery in a very tailored and specialized way. Capabilities Li & Fung achieve their high level of service through an executive relationship of two close brothers who form a unique synergy of strategy and execution. In addition, they give senior managers sufficient autonomy to respond to needs of specific customers. They are aided by a centralized IT as well as financial and administrative support in Hong Kong. Managers have their own compensation package, and bonuses are based on profits with no ceiling. There is great incentive to achieve goals. Li & Fung use a three year planning approach in which a goal is established and a gap analysis aids in identifing steps to get there. Each three year plan had a short name or slogan for the ultimate goal. Through strategic acquisitions to expand reach of service into new markets such as Europe and India, Li & Fung had grown to nearly five times that of its closest competitor by 2000. Value The value Li & Fung provided its clients is the view and reach into a global range of choices for performing tasks. Through their knowledge of the various raw materials suppliers, manufacturers and shippers, Li & Fung could provide a high degree of quality and reliability in all aspects of order fulfillment. This knowledge coupled with sophisticated centralized information management made its services quick and reliable. Threat of Competitors The threat of e-commerce over the Internet was not as direct as expected. The brothers were concerned about disintermediation but found that most Internet businesses were not well conceived. Instead they learned that the threat came from the hype of Internet businesses capturing more investment capital thus enabling those companies to invest greatly in their companies and hire away talent from Li & Fung, for example. Continuing Threats In the next three year plan, Li & Fung will need to assess the possibility and cost/benefit of end-to-end supply chain communications based on improved technology in developing countries. Li & Fung maintain their own staff, on the ground, with each supplier, thus ensuring valid business data in their system. From a market assesment viewpoint they will have to prove the value of that cost versus other entrants into this field that may assess suppliers differently. Channel conflict would continue to be a threat with each increasing IT improvement. They will also need to attend to the legacy clients and how they fare against the B2B portal. Li & Fung 1. What has been the historic strength and strategy for Li and Fung? Since Li and Fung was founded in 1906, the company has more than 100 years of history and it is the main historic strength of Li and Fung. It accumulated lots of information and experience, which other competitors couldn’t have owned without such a strong historic background. Li and Fung is a publicly traded family company. Speed, Solidarity, authenticity, trust, and control are the benefits to running a family business.For example, in a family business, people can think something in the morning and begin working on it in the afternoon; after all, the family is a natural team. Trust is essential in all business and family businesses get a high level of trust among family members. In the early 1970s, Fung brothers who were both educated at Harvard Business School returned from the United States. Fung brothers’ returned heralded Li and Fung’s transition from a family- owned business to a professio nally managed firm, with a planning and budgeting system in place for the first time.As more source of supply emerged in the rapidly industrializing Asian economies, Li and Fung expanded its regional network of offices throughout the Asia-Pacific region and this can be contributed to the fact that Li and Fung was Hong Kong based. By 2000, Li and Fung became a $2 billion global export trading company sourcing and managing the global supply chain for high-volume, time-sensitive consumer goods. 69% of Li and Fung’s sales were in the United States and 27% in Europe.With 48 offices in 32 countries, the company provided value-added services across the entire supply chain in a so-called â€Å"borderless† manufacturing environment. Therefore, Li and Fung clients benefited in several ways: supply-chain customization could shorten order fulfillment from three months to five weeks, and this faster turnaround allowed clients to reduce inventory costs. Moreover, in its role as a mi ddleman, Li and Fung reduced matching and credit risks, and also offered quality assurance to its customers.Furthermore, with a global sourcing network and economies of scales. Li and Fung could offer lower cost and more flexible sourcing than its competitors. Li and Fung even started offering clients virtual manufacturing, or product design services. Li and Fung was entrepreneurial, allowing senior managers to run 90 small, worldwide management teams as separate and individual companies. These dedicated teams of product specialists focused on the needs of specific customers and were grouped under a Li and Fung corporate mbrella that provided centralized IT, financial and administrative support form Hong Kong. This decentralized corporate structure allowed for adaptability and rapid reaction to seasonal shifts. In Li and Fung, performance-based promotion and compensation were cardinal principles. Each Li and Fung’s top executives negotiated individual compensation packages. L i and Fung bonuses were based on profits without ceiling.

Learning and Advertisement Essay

Q: 1 Does this advertisement informed me? Yes it does. It is advertisement by TAPAL family mixture. I learned from this add that how we live in our family? And how to do respect others. And also tells the importance of a family and relations that are very important for everyone. This advertisement tells that relations and happiness makes a complete home. This is important for every to know how to make a family and how to live in a family especially for girls this is very knowledgeable advertisement. Q:1 b) What did you get from this advertisement? I know from this advertisement about a happy family and the importance of a complete family. And how they live in a joined family with love and care. This advertisement conveys a message to young generation to do respect the elders. Q:1 c) Where you can apply this awareness? I can apply this awareness at my home, to do the respect of my elders and love with my younger’s, and also take care of my family members. And informed my friends that they should also see this advertisement and learn the lesion that how to make a complete home. Q: 2 Does this advertisement claim anything? Yes it does. It claims that TAPAL family mixture is a complete tea, and makes a complete home or family. That’s why most of people who are emotional they targeted to buy this product. Q: 3 Does this advertisement use pressure selling? Yes it does. Because it targeting the emotions of people. Target our family and inspired specially girls who are married and want to beautiful and complete home. Use some sentences that show pressure selling. Q: 4 Does this advertisement fulfill the criteria of business ethics? Yes it does because the language which used in this advertisement is good, which is not cross the limits, and we see this advertisement with our family members. This advertisement shows the positive impact on people. Overall environment of this advertisement is good and we learn so many things from this advertisement, this advertisement shows our culture and spread a message that how to live in a family, and make a happy family. www. youtube. com/watch? v=ekHv1IY9_Bc.